Biochemistry involves the study of biological processes at the level of good molecules. We can see how an organism develops, feeds, and performs all its vital functions. Still, it is necessary to emphasize that all these processes result from reactions between molecules that are part of the cells themselves as well as the environment surrounding them.
These chemical reactions perfectly organize and regulated and translate into an adequate cellular behavior giving rise to the beautiful life process.
Our organism comes from a single cell that, through successive divisions and differentiation (all this occurs through biochemical interactions), gives rise to the complete individual. These cellular processes are perfectly regulated and influenced by lineage, that is, genes and their behavior, position information, “neighboring cells” and the chemical environment, the molecules surrounding the cells.
Functions of Good Molecules
The alteration of the adequate cellular functions supposes the molecular base of the pathologies, and on some occasions, the organism itself presents resources to counteract the failure. For example, we all know the regeneration capacity of specific tissues such as bone, liver, and blood.
In the beginning, when the molecules that participate in any cellular process present alterations. So, we are obliged to understand the mechanisms involved to alleviate the problem.
This approach, like so many investigations, carried out from the point of view of biochemistry, led years ago to understand the functioning of the hematopoietic precursors present in umbilical cord blood, and therefore today, we wanted to highlight the UCS Donation as a fact of great
CSIC researchers have identified molecules that inhibit the interaction of the SARS-CoV-2 spike protein with cell receptors and block its access into the compartment and could be used to create antivirals against infection.
They Find Good molecules that stop the Entry of the Coronavirus into Cells
Stopping the entry of SARS-CoV-2, the coronavirus that causes COVID-19, into human cells could be possible thanks to a series of molecules discovered by a team of researchers from the Advanced Council for Scientific Research (CSIC). These molecular compounds, identified as virus entry inhibitors, prevent the coronavirus from entering and infecting cells by inhibiting the interaction between the spike protein of the virus and cell receptors, so it could be a new option to develop antiviral drugs.
When SARS-CoV-2 enters the body, its spicules are responsible for breaking through to the cell. So, something like a master key capable of opening the door of the cell. And Also, once inside is when the interaction between this begins protein and cell receptors, that is, it is the moment where the infection starts.
The identified good molecules can slow the hyperactivation of the immune system that triggers the cytokine storm. Thus, which causes severe COVID-19 cases
This discovery could paralyze the hyperactivation of the immune system. So, which is responsible for unleashing the famous cytokine storm. Also, which occurs in the most severe cases of COVID-19.
In addition, the ability of new molecules to interfere with the bonding between the spike protein. And also the cell receptor will analyze.
Stop Entry without Generating Toxicity in cells
“We have accomplished the embarrassment of the entry of the virus at low attentions. Thus, without engendering toxicity in the host cells.
It generates a broad selectivity index. Hence, a constraint that measures the difference in absorptions between antiviral action and toxicity counter to uninfected cells.
It is an important factor when it comes to developing antiviral drugs ”,
These compounds can act in the early stages of the viral replicative cycle. Hence, their use as a preventive treatment against SARS-CoV-2 could be valued.
These identified compounds can act in the early stages of the viral replicative cycle. By slowing down the virus replication in the cell, they could avoid the effects generated in the cytokine storm. Thus, even the researchers explain that could evaluate its use as a preventive treatment for infection with SARS-CoV-2.
The next step of this research consists of a long journey that includes a preclinical study. Also, an efficacy evaluation in an animal model. In this way, the results obtained will corroborate and, if they correspond to the current ones, work will begin. In interesting antiviral drugs in the fight against the